These impairments may present a risk in situations where these abilities are especially important, such as driving or operating other machinery. Severe hypoglycemia can lead to unconsciousness or convulsions and may result in temporary or permanent impairment of brain function or death. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Some of the side effects that can occur with glipizide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects.
In a placebo-controlled, crossover study in normal volunteers, glipizide had no antidiuretic activity and, in fact, led to a slight increase in free water clearance. Before using this medication, women of childbearing age should talk with their doctors about the risks and benefits. Tell your doctor if you are or if you plan to become pregnant. Store Glucotrol XL in a dry place, in its original container.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with glipizide or any other anti-diabetic drug. The metabolism of glipizide is extensive and occurs mainly in the liver. The primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine. Less than 10% unchanged glipizide is found in the urine. The half-life of elimination ranges from 2 to 4 hours in normal subjects, whether given intravenously or orally. The metabolic and excretory patterns are similar with the 2 routes of administration, indicating that first-pass metabolism is not significant.
Store Serevent Diskus at room temperature away from moisture, heat, and sunlight. Glipizide and Metformin HCl Tablets are not recommended for use during pregnancy or for use in pediatric patients. The initial and maintenance dosing of Glipizide and Metformin HCl Tablets should be conservative in patients with advanced age, due to the potential for decreased renal function in this population. Any dosage adjustment requires a careful assessment of renal function. Generally, elderly, debilitated, and malnourished patients should not be titrated to the maximum dose of Glipizide and Metformin HCl Tablets to avoid the risk of hypoglycemia. Monitoring of renal function is necessary to aid in prevention of metformin-associated lactic acidosis, particularly in the elderly.
The benefit of megadoses of vitamins is highly uncertain, according to the ADA's January 2003 position statement. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. But it is important for your diet to contain all the vitamins you need. The body needs this mineral to regulate blood sugar, but the ADA says taking a chromium supplement wouldn't do most people with diabetes any good. Research shows that chromium supplements can help those who have too little chromium, but most don't have a deficiency. There have been reports of obstructive symptoms in patients with known strictures in association with the ingestion of another drug with this non-dissolvable extended release formulation. Avoid use of Glucotrol XL in patients with preexisting severe gastrointestinal narrowing pathologic or iatrogenic. The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members. Primary and secondary failure should also be explained. In addition, each tablet contains the following inactive ingredients: Sodium Starch Glycolate, Corn Starch, Povidone, Magnesium Stearate, Colloidal Silicon Dioxide, Hypromellose, Talc, Titanium Dioxide, Polyethylene Glycol 6000, Propylene Glycol and Iron Oxide Red. The tablets are film coated, which provides color differentiation. Glucotrol may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Glucotrol with caution. Despite controversy regarding the interpretation of these results, the findings of the UGDP study provide an adequate basis for this warning. The patient should be informed of the potential risks and advantages of Glipizide and of alternative modes of therapy. Hemodialysis has often resulted in reversal of symptoms and recovery. Hepatobiliary: Cholestatic and hepatocellular forms of liver injury accompanied by jaundice have been reported rarely in association with Glipizide; Glipizide should be discontinued if this occurs. Glipizide due to potential overlapping of drug effect.
Glucotrol has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received Glucotrol alone and following treatment with 100 mg of DIFLUCAN as a single daily oral dose for 7 days. Glipizide and metformin medical facts from Drugs. National Center for NCCAM. GLUCOTROL XL every day to help keep your blood sugar level under good control. If should occur in such patients, it may be prolonged and appropriate management should be instituted. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. What should I avoid while taking glipizide Glucotrol? Lab tests, including fasting blood glucose, hemoglobin A 1c, and liver function, may be performed while you take Glucotrol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Tell your doctor or dentist that you take Glucotrol before you receive any medical or dental care, emergency care, or surgery. Do not give Serevent to a child younger than 4 years old. paxil
If you also use a steroid medication, do not stop using the steroid suddenly or you may have unpleasant withdrawal symptoms. Talk with your doctor about taking less and less of the steroid before stopping completely. The pharmacokinetics of glipizide has not been evaluated in patients with hepatic impairment. Serious. These medicines may interact and cause very harmful effects. Prolonged severe hypoglycemia 4 to 10 days has been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of delivery. This has been reported more frequently with the use of agents with prolonged half-lives. If Glipizide is used during pregnancy, they should be discontinued at least one month before the expected delivery date. Do I need a prescription for salmeterol? Cholestatic and hepatocellular forms of liver injury accompanied by jaundice have been reported rarely in association with glipizide; Glipizide and Metformin HCl Tablets should be discontinued if this occurs. mmon.info mebendazole
If you experience pale skin, blurred vision, loss of consciousness, increased thirst, increased urination, fatigue, or fast, deep breathing, check your blood sugar, stop using your antibiotic and contact your doctor right away. Glucotrol included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. FDA pregnancy category C. It is not known whether Serevent will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Store at room temperature away from light and moisture. Different brands of this have different storage needs. Q5. Does Glipizide and Metformin HCl Tablets work differently from other glucose-control medications? When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Consuming alcohol with your medicine may lead to hypoglycemia, a condition in which your blood glucose levels are too low. Symptoms of low blood sugar include pale skin, blurred vision, loss of consciousness, increased thirst, increased urination, blurred vision, fatigue, or fast, deep breathing. C. Brief storage at temperatures between 59 and 86 degrees F 15 and 30 degrees C is permitted. Store away from heat, moisture, and light. Do not store in the bathroom.
Use Glucotrol XL extended-release tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood sugar levels. Low blood sugar levels may also be more difficult to recognize in the elderly. Glipizide is a whitish, odorless powder with a molecular formula of C 21 H 27 N 5 O 4 S, a molecular weight of 445. Chlorpropamide- and tolbutamide-alcohol flushing in non-insulin-dependent diabetes. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Brogden RN, Heel RC, Pakes GE, Speight TM, Avery GS "Glipizide: a review of its pharmacological properties and therapeutic use. epogen patch price india
Advise the patient to read the FDA-approved patient labeling Patient Information. The metabolism of glipizide is extensive and occurs mainly in the liver. The primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine. Less than 10% unchanged glipizide is found in the urine. If after the first three months of therapy glycemic control was inadequate, the glipizide dose may be increased. All sulfonylurea drugs are capable of producing severe hypoglycemia. Proper patient selection, dosage, and instructions are important to avoid hypoglycemic episodes. Renal or hepatic insufficiency may cause elevated blood levels of Glucotrol and the latter may also diminish gluconeogenic capacity, both of which increase the risk of serious hypoglycemic reactions. Elderly, debilitated or malnourished patients, and those with adrenal or pituitary insufficiency, are particularly susceptible to the hypoglycemic action of glucose-lowering drugs. Hypoglycemia may be difficult to recognize in the elderly, and in people who are taking beta-adrenergic blocking drugs. Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, when alcohol is ingested, or when more than one glucose-lowering drug is used. Tell your doctor or dentist that you take Glucotrol XL extended-release tablets before you receive any medical or dental care, emergency care, or surgery. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Some patients may be effectively controlled on a once-a-day regimen, while others show better response with divided dosing. Total daily doses above 15 mg should ordinarily be divided. See USP Controlled Room Temperature. As with other sulfonylurea-class hypoglycemics, no transition period is necessary when transferring patients to Glipizide. Continue to take Glucotrol even if you feel well. Do not miss any doses. When this happens, sugar glucose builds up in the blood. This can lead to serious medical problems, including kidney damage, amputations, and blindness. Diabetes is also closely linked to heart disease. The main goal of treating diabetes is to lower your blood sugar to a normal level. Short-term administration of Glipizide Tablets may be sufficient during periods of transient loss of control in patients usually controlled well on diet. Pfizer internet site at www. Read the Patient Information Leaflet if available from your pharmacist before you start taking glipizide and each time you get a refill. If you have any questions, ask your doctor or pharmacist. GLUCOTROL XL will harm your unborn baby. For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. buy lisinopril adelaide
The maximum recommended dose is 20 mg once daily. Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Glipizide and Metformin HCl Tablets, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from a patient receiving Glipizide and Metformin HCl Tablets, the patient should be observed closely for hypoglycemia. Metformin is negligibly bound to plasma proteins and is, therefore, less likely to interact with highly protein-bound drugs such as salicylates, sulfonamides, chloramphenicol, and probenecid as compared to sulfonylureas, which are extensively bound to serum proteins. Studies characterizing the pharmacokinetics of glipizide in pediatric patients have not been performed. Swallow Glucotrol XL extended-release tablets whole. Do not break, crush, or chew before swallowing. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Dermatologic side effects frequently disappear with continued therapy. Photosensitivity has been reported with other sulfonylureas. Moder KG, Schwenk NM "A coproporphyria-like syndrome induced by glipizide. The recommended starting dose is 5 mg, given before breakfast. Re-evaluate eGFR 48 hours after the imaging procedure; restart Glipizide and Metformin HCl Tablets if renal function is stable. The effectiveness of any oral hypoglycemic drug, including Glucotrol, in lowering blood glucose to a desired level decreases in many patients over a period of time, which may be due to progression of the severity of the diabetes or to diminished responsiveness to the drug. This phenomenon is known as secondary failure, to distinguish it from primary failure in which the drug is ineffective in an individual patient when first given. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Blood sugar control persists in some patients for up to 24 hours after a single dose of Glucotrol, even though plasma levels have declined to a small fraction of peak levels by that time see below. There is no information regarding the effects of hepatic impairment on the disposition of glipizide. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure convulsions. What should I avoid while taking Glucotrol XL glipizide? It is not known whether salmeterol inhalation passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
The metabolism of Glipizide is extensive and occurs mainly in the liver. The primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine. Less than 10% unchanged Glipizide is found in the urine. Nevertheless, it may be possible for complementary treatments to have bad interactions with prescription diabetes drugs. Laboratory Tests: Mild to moderate elevations of ALT, LDH, alkaline phosphatase, BUN and creatinine have been noted. The relationship of these abnormalities to glipizide is uncertain. Side Effects List Glipizide side effects by likelihood and severity. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. See Question Nos. 9-12. Your pharmacist can provide more information about glipizide. Check the labels on all your medicines such as -and-cold products because they may contain ingredients that could affect your sugar. Ask your pharmacist about using those products safely. If you notice any signs or symptoms of low blood sugar or alcohol intolerance, contact your healthcare professional. Your doctor may want you to check your blood sugar more frequently or adjust your medicine. Patients with hepatic impairment have developed cases of metformin-associated lactic acidosis. This may be due to impaired lactate clearance resulting in higher lactate blood levels. Therefore, avoid use of Glipizide and Metformin HCl Tablets in patients with clinical or laboratory evidence of hepatic disease. What should I discuss with my healthcare provider before taking Glucotrol XL glipizide? WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Some MEDICINES MAY INTERACT with Glucotrol XL extended-release tablets. The pattern of laboratory test abnormalities observed with Glucotrol was similar to that for other sulfonylureas. Occasional mild to moderate elevations of SGOT, LDH, alkaline phosphatase, BUN, and creatinine were noted. One case of jaundice was reported. The relationship of these abnormalities to Glucotrol is uncertain, and they have rarely been associated with clinical symptoms. generic flonase buy pharmacy canada
Can Herbs and Diabetes Drugs Mix? Alcohol is known to potentiate the effect of metformin on lactate metabolism. Patients, therefore, should be warned against excessive alcohol intake, acute or chronic, while receiving Glipizide and Metformin HCl Tablets. Learn the symptoms of high and low blood sugar and how to treat low blood sugar. Check your blood sugar levels regularly as directed. Lack of specificity for familial non-insulin dependent diabetes. Check with your doctor before you drink alcohol while you are taking Glucotrol. Alcohol may increase the risk of low blood sugar. Rarely, alcohol may interact with Glucotrol and cause a serious reaction with symptoms such as flushing, nausea, vomiting, dizziness, or stomach pain. Discuss any questions or concerns with your doctor. When such drugs are administered to a patient receiving GLUCOTROL, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving GLUCOTROL, the patient should be observed closely for hypoglycemia. CRTC2 transcription factors, which inhibits genes involved in the production of glucose “gluconeogenic genes”; ii increased AMPK also inhibits mitochondrial glycerol-3-phosphate dehydrogenase mGPD leading to an increase in cytosolic NADH, which both stimulates the conversion of pyruvate to lactate, and simultaneously decreases gluconeogenesis. Take care not to let your blood sugar get too low. Low blood sugar hypoglycemia can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency. There were no clinically meaningful differences in changes from baseline for all lipid parameters between Glipizide and Metformin HCl Tablets therapy and either metformin therapy or glipizide therapy. Glipizide primarily lowers blood glucose by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin. When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma, infection, or surgery, a loss of control may occur. At such times, it may be necessary to discontinue Glucotrol and administer insulin. What brand names are available for salmeterol? Each tablet, for oral administration, contains 5 mg or 10 mg Glipizide. In addition, each tablet contains the following inactive ingredients: anhydrous lactose, microcrystalline cellulose, corn starch, silicon dioxide, stearic acid. FPG versus metformin therapy. Muscles are also the primary site of insulin resistant. The pattern of laboratory test abnormalities observed with glipizide was similar to that for other sulfonylureas. Occasional mild to moderate elevations of SGOT, LDH, alkaline phosphatase, BUN, and creatinine were noted. One case of jaundice was reported. The relationship of these abnormalities to glipizide is uncertain, and they have rarely been associated with clinical symptoms. ranolazine purchase online visa canada
The function of the Glucotrol XL Extended Release Tablet depends upon the existence of an osmotic gradient between the contents of the bi-layer core and fluid in the GI tract. The biologically inert components of the tablet remain intact during GI transit and are eliminated in the feces as an insoluble shell. Prolonged severe hypoglycemia 4 to 10 days has been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of delivery. This has been reported more frequently with the use of agents with prolonged half-lives. If glipizide is used during pregnancy, it should be discontinued at least one month before the expected delivery date. The mean volume of distribution was approximately 10 liters after single intravenous doses in patients with type 2 diabetes mellitus. Medicines are sometimes prescribed for purposes other than those listed in a patient information leaflet. Do not use Glucotrol XL for a condition for which it was not prescribed. Do not give Glucotrol XL to other people, even if they have the same symptoms you have. It may harm them. When colesevelam is coadministered with glipizide extended-release tablets, maximum plasma concentration and total exposure to glipizide is reduced. Therefore, Glipizide Tablets should be administered at least 4 hours prior to colesevelam. Ask your doctor how to adjust your glipizide dose if needed. Do not change your medication dose or schedule without your doctor's advice. Monitor patients closely for hypoglycemia when Glucotrol XL is co-administered with fluconazole. This should also be printed on the label of your prescription. You will probably be started on a low dose of Glipizide and Metformin HCl Tablets and your dosage will be increased gradually until your blood sugar is controlled. Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior . This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated 50% glucose solution. Communication - May Cause Symptoms of Alcohol Intoxication. American Association of Diabetes Educators. Check the labels on all your medicines such as or -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Despite controversy regarding the interpretation of these results, the findings of the UGDP study provide an adequate basis for this warning. The patient should be informed of the potential risks and advantages of glipizide and of alternative modes of therapy. When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma, infection, or surgery, a loss of control may occur. At such times, it may be necessary to discontinue Glipizide and administer insulin. If you miss a dose of Glucotrol XL extended-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. This warning is based on the study conducted by the University Group Diabetes Program UGDP a long-term prospective clinical trial designed to evaluate the effectiveness of glucose-lowering drugs in preventing or delaying vascular complications in patients with non-insulin-dependent diabetes. The study involved 823 patients who were randomly assigned to one of four treatment groups Diabetes, 19, supp. 2: 747-830, 1970. If you have signs or symptoms of low blood sugar, eat or drink something with sugar in it right away. If you do not feel better or your blood sugar level does not go up, call your healthcare provider or go to the nearest emergency room. Although only one drug in the sulfonylurea class tolbutamide was included in this study, it is prudent from a safety standpoint to consider that this warning may also apply to other oral hypoglycemic drugs in this class, in view of their close similarities in mode of action and chemical structure. Glucotrol works best if it is taken at the same time each day. Take this medication by mouth 30 minutes before breakfast or the first meal of the day as directed by your doctor, usually once daily. Some patients, especially those taking higher doses, may be directed to take this drug twice a day. The dosage is based on your medical condition and response to treatment. See window for lot number and expiration date. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Glucotrol XL extended-release tablets exactly as prescribed, tell your doctor. It is not known whether glipizide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. redustat
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Glipizide and Metformin HCl Tablets can have other serious side effects. See " What are the possible side effects of Glipizide and Metformin HCl Tablets? Blood sugar control persists in some patients for up to 24 hours after a single dose of glipizide, even though plasma levels have declined to a small fraction of peak levels by that time see below. In initiating treatment for type 2 diabetes, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia. The importance of regular physical activity should also be stressed, and cardiovascular risk factors should be identified and corrective measures taken where possible. Use of Glucotrol or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint. Furthermore, loss of blood glucose control on diet alone may be transient, thus requiring only short-term administration of Glucotrol or other antidiabetic medications. Maintenance or discontinuation of Glucotrol or other antidiabetic medications should be based on clinical judgment using regular clinical and laboratory evaluations.
Some of these side effects may decrease after you have been using this for a while. If any of these effects persist or worsen, tell your doctor or promptly. Because of the extensive protein binding of GLUCOTROL, is unlikely to be of benefit. Although it is not known whether GLUCOTROL is excreted in human milk, some sulfonylurea drugs are known to be excreted in human milk. Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. If the drug is discontinued and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.
In a placebo-controlled, crossover study in normal volunteers, Glipizide had no antidiuretic activity and, in fact, led to a slight increase in free water clearance. This container provides light-resistance. The risk of metformin-associated lactic acidosis increases with the patient's age because elderly patients have a greater likelihood of having hepatic, renal, or cardiac impairment than younger patients. Assess renal function more frequently in elderly patients. Throat and upper airway irritation can occur.
Tablet is similar in appearance to a conventional tablet. He says he thinks that Reiki could, in theory, act on the 's pain centers and alter one's perception of pain. Glucotrol XL treated patients than those receiving placebo. These may be transient and may disappear despite continued use of glipizide XL; if skin reactions persist, the drug should be discontinued.